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  • August 12 , 2020

    Flipping a metabolic switch to slow tumor growth

    The enzyme serine palmitoyl-transferase can be used as a metabolically responsive "switch" that decreases tumor growth, according to a new study by a team of San Diego scientists, who published their findings Aug. 12 in the journal Nature.
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  • August 11 , 2020

    New machine learning tool predicts devastating intestinal disease in premature infants

    Necrotizing enterocolitis (NEC) is a life-threatening intestinal disease of prematurity. Characterized by sudden and progressive intestinal inflammation and tissue death, it affects up to 11,000 premature infants in the United States annually, and 15-30% of affected babies die from NEC. Survivors often face long-term intestinal and neurodevelopmental complic
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  • August 10 , 2020

    Researchers characterize important regulators of tissue inflammation, fibrosis and regeneration

    Although macrophages (cells involved in the detection and destruction of bacteria and other harmful organisms as well as dead cells) are classified as immune cells functioning in the activation and resolution of tissue inflammation, it is now clear that they are critically involved in a variety of disease processes, such as chronic inflammatory diseases, tum
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  • July 30 , 2020

    Researchers discover new set of channels connecting malaria parasite and blood cells

    Researchers at the National Institutes of Health and other institutions have discovered another set of pore-like holes, or channels, traversing the membrane-bound sac that encloses the deadliest malaria parasite as it infects red blood cells. The channels enable the transport of lipids—fat-like molecules—between the blood cell and parasite, Plasmodium falcip
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  • July 30 , 2020

    Investigational breast cancer vaccine plus immune therapy work well in tandem

    A vaccine for HER2-positive breast cancers that is being tested in a clinical trial at Duke Cancer Institute is part of an effective, two-drug strategy for enlisting the immune system to fight tumors, according to a Duke-led study in Clinical Cancer Research, a journal of the American Association for Cancer Research.
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  • July 29 , 2020

    Researchers detangle protein interaction implicated in Down syndrome and Alzheimer's

    From the movement of a finger to the creation of a memory, actions of the human body require the harmonious concert of protein interactions. A system of checks and balances ensures proper coordination of biomolecules, but when the scale is tipped, lopsided molecular relationships can lead to disorders and diseases. Discovering how proteins interact with one
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  • July 29 , 2020

    Engineers find thinner tissues in replacement heart valves create problematic flutter

    You're in the middle of the aorta, the body's pipeline for oxygen-rich blood, looking back toward the heart's primary pump, the left ventricle.
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  • July 28 , 2020

    Artificial intelligence finds patterns of mutations and survival in tumour images

    Researchers at EMBL's European Bioinformatics Institute (EMBL-EBI), the Wellcome Sanger Institute, Addenbrooke's Hospital in Cambridge, UK, and collaborators have developed an artificial intelligence (AI) algorithm that uses computer vision to analyze tissue samples from cancer patients. They have shown that the algorithm can distinguish between healthy and
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  • July 28 , 2020

    Higher BPA levels linked to more asthma symptoms in children

    Children in low-income neighborhoods in Baltimore tended to have more asthma symptoms when levels of the synthetic chemical BPA (Bisphenol A) in their urine were elevated, according to a study from researchers at the Johns Hopkins Bloomberg School of Public Health and School of Medicine.
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  • July 27 , 2020

    Study shows three medications currently on the market may have unexpected effects

    A new study of 1,443 medications found that three prescription drugs currently on the market caused unexpected changes in worms that could point to potential, unrecognized effects in humans. The study shows that a microscopic nematode worm called C. elegans, which is commonly used in biology experiments, can serve as a quick, inexpensive tool to identify ta
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  • July 27 , 2020

    Artificial intelligence identifies prostate cancer with near-perfect accuracy

    A study published today in The Lancet Digital Health by UPMC and University of Pittsburgh researchers demonstrates the highest accuracy to date in recognizing and characterizing prostate cancer using an artificial intelligence (AI) program. "Humans are good at recognizing anomalies, but they have their own biases or past experience," said senior author Raji
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  • July 26 , 2020

    Antibiotics alone successfully treat uncomplicated appendicitis in children

    Appendicitis is the most common cause for emergency abdominal surgery in childhood, affecting 80,000 children in the United States each year, but nonoperative treatment options are viable. A study performed by the Midwest Pediatric Surgery Consortium, led by Peter Minneci, MD, and Katherine Deans, MD, co-founders and directors of the Center for Surgical Outc
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