Researchers characterize important regulators of tissue inflammation, fibrosis and regeneration
August 10 , 2020

 that display prominent muscle inflammation. Duchenne muscular dystrophy is the most common genetic muscle disease. It causes severe disability and caused by breathing and heart muscle weakness. Currently, the disease has no cure.

"Macrophages are important effectors and regulators of muscle inflammation, fibrosis and regeneration. Our findings build a  for future studies of resident macrophages in skeletal muscle development, injury repair and diseases with prominent muscle inflammation," explained corresponding author Lan Zhou, MD, Ph.D., professor of neurology at BUSM. "Understanding their respective origins, tissue-specific characteristics and disease-related functions is absolutely essential to harness their therapeutic potential."

Zhou and her team used experimental models to allow macrophage lineage tracing and performed bone marrow transplant experiments to study the origins of skeletal muscle resident macrophages. They also performed single cell-based transcriptome analyses to analyze subsets of skeletal muscle resident macrophages and their functions.

These findings appear online in the journal PNAS.

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