Experimental treatment confers benefits for the alleviation of nonalcoholic hepatic steatosis
August 13 , 2020
by Liu Jia,  

 were the key factors that contributed to the therapeutic effects of GMD on NAFLD. Four folate-producing bacteria, Bacteroides xylanisolvens, B. thetaiotaomicron, B. dorei, and B. uniformis, enriched by GMD were identified. This is the first report about the ability for these four intestinal bacteria to produce folate. 

Furthermore, oral administration of live B. xylanisolvens, which is the bacterium most boosted by GMD, alleviated hepatic steatosis in mice with the activation of folate-mediated signaling pathways. To validate the role of gut-produced folate in NAFLD, the researchers generated a folate-deficient strain of B. xylanisolvens (BXΔfolP) by knocking out the folp gene in the folate biosynthetic pathway. Gavages with BXΔfolP failed to alleviate NAFLD in mice. 

This study demonstrates the anti-NAFLD effect of a Ganoderma-derived compound, identifies a specific and useful gut Bacteroides-Folate-Liver Axis for the treatment of NAFLD, and discovers a group of potential probiotics beneficial for the prevention of NAFLD. The finding opens up a new perspective for future NAFLD drug discovery and broadens the scope of NAFLD treatments.

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